The Granulomatous Disorders.
نویسندگان
چکیده
منابع مشابه
Granulomatous disorders.
Almost all granulomatous skin disorders can cause red lesions on the face. Such disorders may include many bacterial, fungal, or parasitic infections, noninfectious inflammatory disorders, foreign body reactions, and even neoplasms. Clinically, they usually present with papules, plaques, nodules, and/or abscesses, which may ulcerate. It may be helpful in their differential diagnosis to define c...
متن کاملA clinicopathological classification of granulomatous disorders.
Granulomatous disorders comprise a large family sharing the histological denominator of granuloma formation. A granuloma is a focal compact collection of inflammatory cells, mononuclear cells predominating, usually as a result of the persistence of a non-degradable product and of active cell mediated hypersensitivity. There is a complex interplay between invading organism or prolonged antigenae...
متن کاملThe Role of the Innate Immune System in Granulomatous Disorders
The dynamic structure of the granuloma serves to protect the body from microbiological challenge. This organized aggregate of immune cells seeks to contain this challenge and protect against dissemination, giving host immune cells a chance to eradicate the threat. A number of systemic diseases are characterized by this specialized inflammatory process and granulomas have been shown to develop a...
متن کاملStatins: novel weapons against granulomatous disorders and HIV infection?
The adhesion molecules LFA-1 and ICAM-1 are considered to be critically involved in cell fusion and multinucleated giant cell (MGC) formation (1). Alveolar macrophages of patients with pulmonary sarcoidosis show increased expression of LFA-1 and ICAM1 (2) and, importantly, it has been shown that MGC formation can be blocked by anti-LFA-1 and anti-ICAM-1 antibodies (1). LFA-1/ICAM-1 interaction ...
متن کاملChronic granulomatous disease and other disorders of phagocyte function.
The analysis of specific gene defects in disorders of phagocyte function has shed light on important aspects of the innate immune response. Each disorder has distinctive features in the clinical presentation and characteristic microbial pathogens. Chronic granulomatous disease has been extensively studied both in patient series and in mouse models. New insights continue to be obtained regarding...
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ژورنال
عنوان ژورنال: Postgraduate Medical Journal
سال: 2001
ISSN: 0032-5473
DOI: 10.1136/pmj.77.906.286e